Comments for Ouroboros http://ouroboros.wordpress.com Research in the biology of aging Sun, 06 Jul 2008 13:32:28 +0000 http://wordpress.org/?v=MU Comment on Evolutionary theories of aging, as applied to lifespan extension by ouroboros http://ouroboros.wordpress.com/2008/07/02/evolutionary-theories-of-aging-as-applied-to-lifespan-extension/#comment-46284 ouroboros Fri, 04 Jul 2008 21:28:38 +0000 http://ouroboros.wordpress.com/?p=485#comment-46284 That isn't his point, exactly. Rose's point is that in a model where accumulation of damage is constant or accelerating, and that this is the primary cause of aging (where "aging" is a time-dependent loss of fitness), then there shouldn't be mortality plateaus. I'd recommend reading the article; lacking depth and acting on whim are problems that Rose definitely does not have. If you'd like, I can forward you a copy of the PDF --let me know. That isn’t his point, exactly. Rose’s point is that in a model where accumulation of damage is constant or accelerating, and that this is the primary cause of aging (where “aging” is a time-dependent loss of fitness), then there shouldn’t be mortality plateaus.

I’d recommend reading the article; lacking depth and acting on whim are problems that Rose definitely does not have. If you’d like, I can forward you a copy of the PDF –let me know.

]]> Comment on Evolutionary theories of aging, as applied to lifespan extension by Al Fin http://ouroboros.wordpress.com/2008/07/02/evolutionary-theories-of-aging-as-applied-to-lifespan-extension/#comment-46282 Al Fin Fri, 04 Jul 2008 18:12:49 +0000 http://ouroboros.wordpress.com/?p=485#comment-46282 Good point, Mstudent. The same should be true for chimps and gorillas, social apes.We need to get more accustomed to out of the box evolutionary reasoning. I haven't read Rose's article, but the whim that survival curve "plateaus" imply that "aging" is not happening during those time periods, lacks depth. Good point, Mstudent. The same should be true for chimps and gorillas, social apes.We need to get more accustomed to out of the box evolutionary reasoning.

I haven’t read Rose’s article, but the whim that survival curve “plateaus” imply that “aging” is not happening during those time periods, lacks depth.

]]> Comment on Evolutionary theories of aging, as applied to lifespan extension by Michael http://ouroboros.wordpress.com/2008/07/02/evolutionary-theories-of-aging-as-applied-to-lifespan-extension/#comment-46277 Michael Thu, 03 Jul 2008 14:39:12 +0000 http://ouroboros.wordpress.com/?p=485#comment-46277 All: I find Dr. Rose's ideas about lifelong metabolic adaptations fascinating, but do not believe that they actually underlie biological aging in a way that is not ultimately mediated through the kind of cellular and molecular damage that SENS (and the biogerontological mainstream) accepts, and whose repair, removal, replacement, or rendering harmless forms the basis for SENS as an intervention platform. Before this specific controversy arose, Dr. de Grey had already offered what appears to be a quite adequate rebuttal to the key basis for Rose's thesis (the basis for the late-life plateau in mortality rates): de Grey ADNJ. Critique of the demographic evidence for "late-life non-senescence". Biochem Soc Trans 2003; 31(2):452-454. PDF: http://www.mfoundation.org/files/sens/manu18.pdf de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesis. Exp Gerontol 2003; 38(8):921-923. PDF: http://www.mfoundation.org/files/sens/muelrep.pdf de Grey ADNJ. Models on trial: falsifying overstated claims of generality does not falsify correctly-stated ones. Exp Gerontol 2004; 39(3):453. PDF: http://www.mfoundation.org/files/sens/Roserep2.pdf Dr. de Grey suggested two ways that Drs. Mueller and Rose could "identify robust evidence against the slope heterogeneity hypothesis [Dr. de Grey's alternative interpretation of the phenomenon] as compared to their model" using tools available to them; they have not yet taken up these suggestions, nor provided any other clear rebuttal to Dr. de Grey's more parsimonious explanation. -Michael All:

I find Dr. Rose’s ideas about lifelong metabolic adaptations fascinating, but do not believe that they actually underlie biological aging in a way that is not ultimately mediated through the kind of cellular and molecular damage that SENS (and the biogerontological mainstream) accepts, and whose repair, removal, replacement, or rendering harmless forms the basis for SENS as an intervention platform.

Before this specific controversy arose, Dr. de Grey had already offered what appears to be a quite adequate rebuttal to the key basis for Rose’s thesis (the basis for the late-life plateau in mortality rates):

de Grey ADNJ. Critique of the demographic evidence for “late-life non-senescence”. Biochem Soc Trans 2003; 31(2):452-454. PDF:
http://www.mfoundation.org/files/sens/manu18.pdf

de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesis. Exp Gerontol 2003; 38(8):921-923. PDF:
http://www.mfoundation.org/files/sens/muelrep.pdf

de Grey ADNJ. Models on trial: falsifying overstated claims of generality does not falsify correctly-stated ones. Exp Gerontol 2004; 39(3):453. PDF:
http://www.mfoundation.org/files/sens/Roserep2.pdf

Dr. de Grey suggested two ways that Drs. Mueller and Rose could “identify robust evidence against the slope heterogeneity hypothesis [Dr. de Grey's alternative interpretation of the phenomenon] as compared to their model” using tools available to them; they have not yet taken up these suggestions, nor provided any other clear rebuttal to Dr. de Grey’s more parsimonious explanation.

-Michael

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by Mir http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46275 Mir Thu, 03 Jul 2008 08:49:42 +0000 http://ouroboros.wordpress.com/?p=471#comment-46275 ouroboros, I aswered, but the entry did not show up in the blog. Thank you for your advice. Mir ouroboros,

I aswered, but the entry did not show up in the blog.

Thank you for your advice.

Mir

]]> Comment on Evolutionary theories of aging, as applied to lifespan extension by Mstudent http://ouroboros.wordpress.com/2008/07/02/evolutionary-theories-of-aging-as-applied-to-lifespan-extension/#comment-46263 Mstudent Wed, 02 Jul 2008 18:22:30 +0000 http://ouroboros.wordpress.com/?p=485#comment-46263 I think that there might well be an overall tendence to inherit post-reproductive lifespan in social beings. Longer lives means that veteran members of the social structure can stay around for longer providing the benefits of their experience to their offspring. Which should result in them having better chances of survival. (Personal opinion based on observation of anecdotal data. But with humans at least it fits.) I think that there might well be an overall tendence to inherit post-reproductive lifespan in social beings. Longer lives means that veteran members of the social structure can stay around for longer providing the benefits of their experience to their offspring. Which should result in them having better chances of survival. (Personal opinion based on observation of anecdotal data. But with humans at least it fits.)

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by ouroboros http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46259 ouroboros Tue, 01 Jul 2008 18:59:07 +0000 http://ouroboros.wordpress.com/?p=471#comment-46259 Mir, I think that asking for medical advice on blogs is a bad idea, generally speaking. I'm sorry if it's tough to ask Austrian doctors about stuff like this, but I still think it's your best bet. The best answer I can give you is that it's unlikely that anyone has carefully studied effect of resveratrol on specific chemotherapeutic agents, so any answer you get from anyone is likely to say more about their own prejudices than anything else. For my part, I think resveratrol is a basically innocuous substance at such low doses, and that it's unlikely to interfere with any modern chemotherapy, and that if it makes your mom feel better to take it then she should keep on taking it. I have no advice about specific formulations or whether higher doses would be useful or harmful. I don't think anyone knows. Mir, I think that asking for medical advice on blogs is a bad idea, generally speaking. I’m sorry if it’s tough to ask Austrian doctors about stuff like this, but I still think it’s your best bet.

The best answer I can give you is that it’s unlikely that anyone has carefully studied effect of resveratrol on specific chemotherapeutic agents, so any answer you get from anyone is likely to say more about their own prejudices than anything else.

For my part, I think resveratrol is a basically innocuous substance at such low doses, and that it’s unlikely to interfere with any modern chemotherapy, and that if it makes your mom feel better to take it then she should keep on taking it. I have no advice about specific formulations or whether higher doses would be useful or harmful. I don’t think anyone knows.

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by Mir http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46257 Mir Mon, 30 Jun 2008 11:00:50 +0000 http://ouroboros.wordpress.com/?p=471#comment-46257 Hi, I need some help of the well informed people from this forum. My mother is diagnosed breast cancer one month ago. She was taking Resveratrol (50 mg), for one year now. She has to do chemotherapy in the next 6 months. Do you think it is good for she to continue taking Resveratrol, and if so, to maybe increase the dosis (like to take Longevinex)? I live in Austria and it is not very popular to ask such questions the physicians. Thanks a lot! Mir Hi,

I need some help of the well informed people from this forum.

My mother is diagnosed breast cancer one month ago. She was taking Resveratrol (50 mg), for one year now. She has to do chemotherapy in the next 6 months.

Do you think it is good for she to continue taking Resveratrol, and if so, to maybe increase the dosis (like to take Longevinex)?

I live in Austria and it is not very popular to ask such questions the physicians.

Thanks a lot!

Mir

]]> Comment on Resveratrol as an antioxidant by Christopher Skauss http://ouroboros.wordpress.com/2007/01/17/resveratrol-as-an-antioxidant/#comment-46256 Christopher Skauss Mon, 30 Jun 2008 09:35:36 +0000 http://ouroboros.wordpress.com/2007/01/17/resveratrol-as-an-antioxidant/#comment-46256 they call the drug SRT501 and it has successfully passed phase 1b clinical trials. A Sirtris spokesman said the company has initiated a phase 2 study of SRT501 in combination with metformin.Still it's at least four years away from market I think they call the drug SRT501 and it has successfully passed phase 1b clinical trials. A Sirtris spokesman said the company has initiated a phase 2 study of SRT501 in combination with metformin.Still it’s at least four years away from market I think

]]> Comment on Stem cells are wasted on the young: The impact of aging on cell therapy… and potential solutions by Mstudent http://ouroboros.wordpress.com/2008/06/23/stem-cells-are-wasted-on-the-young-the-impact-of-aging-on-cell-therapy-and-potential-solutions/#comment-46244 Mstudent Thu, 26 Jun 2008 18:47:25 +0000 http://ouroboros.wordpress.com/?p=482#comment-46244 Postdata: I. Conboy not the only one doing research around those lines, apparently. These guys suppressed that same pathway on Alzheimer-like mice, with good results... http://dx.doi.org/10.1038/nm1781 I guess the million dollar question is whether these things can be ported over... Postdata: I. Conboy not the only one doing research around those lines, apparently. These guys suppressed that same pathway on Alzheimer-like mice, with good results…
http://dx.doi.org/10.1038/nm1781

I guess the million dollar question is whether these things can be ported over…

]]> Comment on “Aging: The Disease, The Cure, The Implications” - this Friday at UCLA by attilachordash http://ouroboros.wordpress.com/2008/06/25/aging-the-disease-the-cure-the-implications-this-friday-at-ucla/#comment-46241 attilachordash Wed, 25 Jun 2008 14:46:16 +0000 http://ouroboros.wordpress.com/?p=483#comment-46241 I post my "live coverage" here: http://friendfeed.com/rooms/understanding-aging-conf http://pimm.wordpress.com/2008/06/15/understanding-aging-conference-on-friendfeed/ I post my “live coverage” here: http://friendfeed.com/rooms/understanding-aging-conf

http://pimm.wordpress.com/2008/06/15/understanding-aging-conference-on-friendfeed/

]]> Comment on On “The Stupidity of Dignity” by Dogheaven http://ouroboros.wordpress.com/2008/06/03/on-the-stupidity-of-dignity/#comment-46239 Dogheaven Tue, 24 Jun 2008 23:24:59 +0000 http://ouroboros.wordpress.com/?p=459#comment-46239 There is a “mortal danger,” he writes, in the notion “that a person has a right over his body, a right that allows him to do whatever he wants to do with it.” Change the word his and he to hers and she and see what you come up with. There is a “mortal danger,” he writes, in the notion “that a person has a right over his body, a right that allows him to do whatever he wants to do with it.”

Change the word his and he to hers and she and see what you come up with.

]]> Comment on Stem cells are wasted on the young: The impact of aging on cell therapy… and potential solutions by Mstudent http://ouroboros.wordpress.com/2008/06/23/stem-cells-are-wasted-on-the-young-the-impact-of-aging-on-cell-therapy-and-potential-solutions/#comment-46238 Mstudent Tue, 24 Jun 2008 06:34:37 +0000 http://ouroboros.wordpress.com/?p=482#comment-46238 I read some days ago about some research group in California that had managed to fix the problem of reduced stem cell proliferation in the elderly by inhibiting TGF-Beta through RNA interference. This is the article that is being tossed around newsites. But it doesn´t say too much http://www.medicalnewstoday.com/articles/111521.php This one from nature likely is more promising. I cant check it from here, but for those who can, here is the link. http://dx.doi.org/10.1038/stemcells.2008.96 I read some days ago about some research group in California that had managed to fix the problem of reduced stem cell proliferation in the elderly by inhibiting TGF-Beta through RNA interference.

This is the article that is being tossed around newsites. But it doesn´t say too much
http://www.medicalnewstoday.com/articles/111521.php

This one from nature likely is more promising. I cant check it from here, but for those who can, here is the link.
http://dx.doi.org/10.1038/stemcells.2008.96

]]> Comment on Intelligent Design: Where politics, religion and stupidity intersect by ouroboros http://ouroboros.wordpress.com/2007/03/15/intelligent-design-where-politics-religion-and-stupidity-intersect/#comment-46217 ouroboros Fri, 20 Jun 2008 22:53:06 +0000 http://ouroboros.wordpress.com/2007/03/15/intelligent-design-where-politics-religion-and-stupidity-intersect/#comment-46217 (Mis)quoting Dawkins in support of ID just makes you sound like a jackass. (Mis)quoting Dawkins in support of ID just makes you sound like a jackass.

]]> Comment on Sweet madness: Sporadic prion disease and age-related changes in protein glycosylation by Gary http://ouroboros.wordpress.com/2006/12/14/sweet-madness-sporadic-prion-disease-and-age-related-changes-in-protein-glycosylation/#comment-46199 Gary Thu, 19 Jun 2008 11:22:48 +0000 http://ouroboros.wordpress.com/2006/12/14/sweet-madness-sporadic-prion-disease-and-age-related-changes-in-protein-glycosylation/#comment-46199 Carol You are the only person, besides myself, who I ever saw/heard express the belief that we are not made to wear out and die! Gary Carol

You are the only person, besides myself, who I ever saw/heard express the belief that we are not made to wear out and die!

Gary

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by ouroboros http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46194 ouroboros Thu, 19 Jun 2008 00:13:15 +0000 http://ouroboros.wordpress.com/?p=471#comment-46194 I don't currently take any form of resveratrol, though as I've commented <a href="/2006/12/01/putting-my-money-where-my-mitochondria-are/" rel="nofollow">before</a>, this is mostly because I don't trust the people who sell it, and I'm not sure what I'd be getting. I'd certainly want to avoid high doses, regardless of the vendor; I'm concerned by reports about malabsorption and chelation issues -- though I'm having a hard time tracking down reputable sources on these points. I don’t currently take any form of resveratrol, though as I’ve commented before, this is mostly because I don’t trust the people who sell it, and I’m not sure what I’d be getting.

I’d certainly want to avoid high doses, regardless of the vendor; I’m concerned by reports about malabsorption and chelation issues — though I’m having a hard time tracking down reputable sources on these points.

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by Mike Jamison http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46187 Mike Jamison Wed, 18 Jun 2008 18:30:37 +0000 http://ouroboros.wordpress.com/?p=471#comment-46187 OK, Ouroboros, how would you bet? I'm betting my life, so how about sharing some well-informed opinion? I really enjoy reading your work. You make me see the inside of the lab! Thanks. Mike OK, Ouroboros, how would you bet?

I’m betting my life, so how about sharing some well-informed opinion?

I really enjoy reading your work. You make me see the inside of the lab! Thanks.

Mike

]]> Comment on The old woman of the sea by Mari. http://ouroboros.wordpress.com/2007/09/04/the-old-woman-of-the-sea/#comment-46185 Mari. Tue, 17 Jun 2008 19:42:18 +0000 http://ouroboros.wordpress.com/2007/09/04/the-old-woman-of-the-sea/#comment-46185 Last i heard Besides human females certain species of whales are the only other species besides humans that go through menopuase. Last i heard Besides human females certain species of whales are the only other species besides humans that go through menopuase.

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by Whole body hacks ? | brainhealthhacks.com http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46184 Whole body hacks ? | brainhealthhacks.com Tue, 17 Jun 2008 15:18:09 +0000 http://ouroboros.wordpress.com/?p=471#comment-46184 [...] is reported to be increased with CR in many tissues. Ouborous has a couple of very good posts on resveratrol and sirtuins [...] [...] is reported to be increased with CR in many tissues. Ouborous has a couple of very good posts on resveratrol and sirtuins [...]

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by ouroboros http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46176 ouroboros Fri, 13 Jun 2008 15:30:50 +0000 http://ouroboros.wordpress.com/?p=471#comment-46176 Thanks Jamie -- I made the correction. Thanks Jamie — I made the correction.

]]> Comment on Low-dose resveratrol as a calorie restriction mimetic by Indiana Doc http://ouroboros.wordpress.com/2008/06/12/low-dose-resveratrol-as-a-calorie-restriction-mimetic/#comment-46175 Indiana Doc Fri, 13 Jun 2008 14:57:18 +0000 http://ouroboros.wordpress.com/?p=471#comment-46175 I just started taking 100 mg of resveratrol (Longevinex) twice a day with my morning and noon meals. I suffer from insulin insensitivity, (metabolic sydrome) the precursor to type two diabetes. What I immediately noticed is that I no longer experience tiredness after consuming carbs. It will be interesting to see what my insulin levels look like after my next Glucose Tolerance Test. I've been taking metaformin by prescription to improve my insulin sensitivity, but haven't seen much effect. I just started taking 100 mg of resveratrol (Longevinex) twice a day with my morning and noon meals. I suffer from insulin insensitivity, (metabolic sydrome) the precursor to type two diabetes. What I immediately noticed is that I no longer experience tiredness after consuming carbs.

It will be interesting to see what my insulin levels look like after my next Glucose Tolerance Test. I’ve been taking metaformin by prescription to improve my insulin sensitivity, but haven’t seen much effect.

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