HAGR: Human Ageing Genomic Resources

(To Bio::Blogs readers: Welcome!)

I just discovered, and am in the process of checking out, Human Ageing Genomic Resources (HAGR) over at senescence.info, a site run by aging researcher João Pedro de Magalhães.

HAGR consists of two main parts: GenAge, a curated database of genes known or suspected to play a role in aging, and AnAge, a resource for comparative study of aging in different organisms (I am guessing that the “An-” comes from “Animal”). AnAge is big, with more than 3900 entries — most at the species level, but also at other limbs of the phylogenetic tree. GenAge is smaller, with only 243 entries, though these are hand-curated descriptions of every gene known to play a role in human aging, so it’s still a lot of information.

There is a bit more to the site, including a software package (the Ageing Research Computational Tools) and references to some tantalizing works in progress. One of these pertains to the evolution of aging in mammals and another (the Delta Projects) looks like it could evolve into a meta-analysis of expression profiles of aging. I find the last point particularly exciting: as someone who has done a bit of work trying to analyze multiple microarray data sets, I’m a firm believer that the more centralized resources there are within a field (to standardize data formats, at the very least), the better.

I’ll continue to explore the site, but I wanted to blog it in case it might come in handy for anyone else. If you want to do more reading, the resources are described in an 2005 article in Nucleic Acids Research.