Here are three of the noteworthy aging-related reviews from the past week.
For the remainder of this coming week, I’ll be devoting this space to a bumper crop of recent papers about Sir2/SIRT1/sirtuin, so be sure to check back.
Hutchison-Gilford progeria: A-type lamin networks in light of laminopathic diseases, Vlcek and Foisner:
… Mutations in A-type lamins cause a variety of diseases from muscular dystrophy and lipodystrophy to systemic diseases such as premature ageing syndromes. The molecular basis of these diseases is still unknown. Here we summarize known interactions of A-type lamins with components of the nuclear envelope and the nucleoplasm and discuss their potential involvement in the etiology and molecular mechanisms of the diseases.
Mitochondrial mutation in worm and human: Long-lived C. elegans Mitochondrial mutants as a model for human mitochondrial-associated diseases, Ventura et al.:
… Over 400 mutations in mitochondrial DNA result directly in pathology and many more disorders associated with mitochondrial dysfunction arise from mutations in nuclear DNA. It is counter-intuitive then, that a class of mitochondrially defective mutants in the nematode Caenorhabditis elegans, the so called Mit (Mitochondrial) mutants, in fact live longer than wild-type animals. In this review, we will reconcile this paradox and provide support for the idea that the Mit mutants are in fact an excellent model for studying human mitochondrial associated diseases (HMADs). …
Animal models and theories of aging: How genetic analysis tests theories of animal aging, Siegfried Hekimi:
Each animal species displays a specific life span, rate of aging and pattern of development of age-dependent diseases. The genetic bases of these related features are being studied experimentally in invertebrate and vertebrate model systems as well as in humans through medical records. Three types of mutants are being analyzed: … Here, I analyze some of what we know today and discuss what we should try to find out in the future to understand the aging phenomenon.