Three very important articles about p16INK4a, senescence and aging were just released in the early-online edition of Nature. I’m still digesting them and will comment here early next week; I don’t want to rush to judgment since these articles are all in my particular field of research, and there’s so much new information that I’m choking a little.
Nonetheless, I wanted to give readers a heads-up. The links are below, and there’s a nonspecialist-oriented summary in the New York Times.
- Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a, Janzen et al.
- p16INK4a induces an age-dependent decline in islet regenerative potential, Krishnamurthy et al.
- Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing, Molofsky et al.