Are antioxidants pro-mortality?

At PharmacoNutrition Reviewed, Sebastian reviews a recent JAMA paper with surprising results: Specific anti-oxidant supplements might actually increase mortality.

First of all, I am curious to read the comments this article will certainly provoke. The widely cited Miller et al. study on vitamin E and mortality, for example, caused a quite heated debate, especially regarding the statistics used.

Secondly, we (at least most of us) are not only consuming nutrients – but food; although I haven’t fully digested this meta-analysis, yet, the results are – if valid – not that surprising, because when antioxidants are taken in as part of real food they actually exert quite different effects I contrast to supplements.