“A singular view of aging”

Jan Vijg‘s book about the role of DNA damage and somatic mutation in the aging process, Aging of the Genome: The Dual Role of DNA in Life and Death, has been reviewed in Nature:

There is no shortage of theories of ageing. Confronted by the terrifying realization of mortality, human ingenuity has created an interesting array of explanations, including toxins produced by gut bacteria (curable by eating yoghurt) and reduced secretions from the testicles (curable by transplants of testicular tissue from monkeys). There is now general agreement that ageing is caused by the accumulation of damage. Key issues are the exact types of damage responsible for functional impairment and death, and the processes that generate this damage and protect against it. Jan Vijg’s excellent book Aging of the Genome makes no concession of equal space for the many candidates subject to current scrutiny. Rather, it critically examines the case for one — somatic mutation.

The reviewer comments that while the text is quite scholarly, it should still be of interest to the nonspecialist reader, but I can’t confirm or deny that until after I receive my copy. I know that Jan is a fantastic scientist and a very clear thinker, so I’m looking forward to it.

(For a description of some of Jan Vijg’s recent experimental work, see our earlier article Genomic instability and transcriptional noise.)

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One comment

  1. Hello,

    I find your blog very interesting, and helpful.

    I am a Ph.D. student at the Montreal Neurological Institute. My current research topic deals with the regulation of COPI mediated retrograde trafficking. Previously, I worked on monoamine transporter function. All work has used biochemical/cell biological approaches to study protein function.

    Recently, I started to seriously consider doing a post-doc studying the molecular mechanisms of aging. A paper from the Linquist group made be think I could continue to study membrane trafficking and it’s relation to aging or age related disease. Could you recommend a couple of the best labs (the west coast is where I would like to live, but it is not mandatory)working in this area?

    Thank you,
    Jonathon Burman

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