More on the aging fly gonad – because you can’t really know too much about the aging fly gonad

If you liked yesterday’s piece about the impact of an aging stem cell niche on Drosophila germ line stem cells, you’ll appreciate this. Leanne Jones (senior author of one of the papers we discussed yesterday) has a full-length review of germ line aging, gametogenesis, the impact of the tissue microenvironment and even a bit about longevity/reproduction tradeoffs (link):

Aging and the germ line: where mortality and immortality meet

Germ cells are highly specialized cells that form gametes, and they are the only cells within an organism that contribute genes to offspring. Germline stem cells (GSCs) sustain gamete production, both oogenesis (egg production) and spermatogenesis (sperm production), in many organisms. Since the genetic information contained within germ cells is passed from generation to generation, the germ line is often referred to as immortal. Therefore, it is possible that germ cells possess unique strategies to protect and transmit the genetic information contained within them indefinitely. However, aging often leads to a dramatic decrease in gamete production and fecundity. In addition, single gene mutations affecting longevity often have a converse effect on reproduction. Recent studies examining age-related changes in GSC number and activity, as well as changes to the stem cell micro- environment, provide insights into the mechanisms underlying the observed reduction in gametogenesis over the lifetime of an organism.

For more on reproductive cells from the perspective of biogerontology, see our earlier post, Germ line immortality vs somatic longevity, about last year’s review by Shawn Ahmed.