This is your brain on CR

If you’re a mouse, anyway. Over at Neurophilosophy, a report on a study that has characterized the transcriptional profile of five segments of the mouse brain. The paper is of particular interest to biogerontologists: samples were taken from young, middle-aged, and old animals, either fed ad libitum or calorie restricted (CR).

Among the findings: synaptic vesicle proteins (which affect signal transmission between neurons) in the hippocampus are highly influenced by age and diet. As analysis continues, perhaps a coherent pattern of gene expression will provide a neurochemical explanation for the relationship between CR and depression in rodents.