Tired old hearts

Following up on yesterday’s post on elastin breakdown in the cardiovascular system, Bernhard and Laufer have a nice comprehensive review on aging cardiomyocytes. The piece includes more about ECM degradation but also includes discussion of oxidative damage, the role of intrinsic and extrinsic factors, and altered gene expression. It’s a good one-stop shop for those curious about aging in this all-important organ.