The Wnt signaling pathway has been implicated in accelerating the aging process by interfering with the action of Klotho, but this claim has met with resistance; there is also emerging evidence that some of Wnt’s effects delay age-related decline in specific tissues. A recent review by DeCarolis et al. describes the controversy and weighs the arguments on all sides.

Another piece by Makato Kuro-o, focused primarily on mechanisms of Klotho action, also discusses the relationship between Klotho and Wnt.