The answer is blowing in the Wnt

The Wnt signaling pathway has been implicated in accelerating the aging process by interfering with the action of Klotho, but this claim has met with resistance; there is also emerging evidence that some of Wnt’s effects delay age-related decline in specific tissues. A recent review by DeCarolis et al. describes the controversy and weighs the arguments on all sides.

Another piece by Makato Kuro-o, focused primarily on mechanisms of Klotho action, also discusses the relationship between Klotho and Wnt.

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