Antioxidant overexpression slows aging in flies

From the Tower lab, a comprehensive gene expression profile of flies that conditionally overexpress the antioxidant enzyme MnSOD. Based on the inverse relationship between genes regulated by MnSOD and those regulated by aging, the authors argue that their flies are experiencing a bona fide delay in the natural aging process. Furthermore, based on results in the worm, the authors conclude that gene regulation by aging is conserved across broad evolutionary distances.