The newest issue of PNAS is bursting with articles about reactive oxygen species (ROS) — which, as we all know, either do or do not contribute to aging.

Most of the papers are hardcore chemistry, but there is one about starvation-induced differential stress resistance (i.e., the use of severe caloric restriction to protect normal cells while leaving cancer cells susceptible to therapeutic toxins). From the editorial intro:

Dioxygen is a highly important, yet toxic, molecule that reacts in vivo to produce reactive oxygen species such as superoxide, peroxides, hydroxyl radicals, and other related species. Those species play important roles in healthy organisms, and they are implicated in aging and a wide range of disease processes as well. The contents of this Special Feature on Reactive Oxygen Species in Chemistry and Biology represents a sampling of the excellent work that is being carried out at this important interface of chemistry and biology by using a wide range of chemical, kinetic, spectroscopic, and biological approaches. The authors come from several different fields and use a wide diversity of techniques and experimental systems; nevertheless, their studies all relate to the fundamental chemical reactivity of dioxygen and species derived from it.

(Hat tip to Baste at PharmacoNutrition Reviewed.)