…is the title of an excellent general review of recent biogerontological findings in model organisms, and their ramifications for intervening in human aging, written by Jan Vijg and Judy Campisi. It’s a very nice piece so don’t let the milquetoast abstract put you off the scent:
Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.
I have it on good authority that the first draft of this review was written by hand, on paper propped up on the dashboard of a car, as the two intrepid authors drove through Holland and Germany on their way to a meeting.