As I was wandering the net today I found a very nice writeup about the 2009 report of an association between the FOXO3A gene and human aging. I found the article at the apparently quite popular but new-to-me blog Singularity Hub.
We mentioned this work in a brief post last year. The overall conclusion is that natural variants in this gene that are associated with extreme longevity. (The FOXO3A gene is a homolog of DAF-16, a longevity determinant in worms.) The 2009 paper describes a study of German centenarians, and is consistent with similar results in Japanese-Americans, published in 2008. Other genetic variants associated with lifespan include the hTERT and hTERC loci, recently described in a study of Ashkenazi Jewish centenarians.
Mostly I’m writing this post to introduce our readers to an interesting site: Singularity Hub contains a lot of excellent biogerontology coverage (in their longevity category). Much of the writing on that topic is by senior editor Aaron Saenz, who does a great job of critically addressing the newest findings in a very reader-friendly and accessible style. I’m going to subscribe to their feed and start reading regularly. Overall it’s a very professional and well-written site, and I’d recommend it to Ouroboros readers.
Do we know the amino acid sequence of the g allele?
please email me if you find out – i’m writing a paper on this!
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