A new and as-yet-unpublished study proposes a causative link between advanced glycation endproducts (AGEs) and DNA damage, potentially explaining the link between diabetes (where frequent blood glucose spikes cause accelerated formation of AGEs) and male infertility. The authors of the study focus on sperm, but the result suggests that AGEs may play a role DNA damage in other tissues as well. Since DNA damage is widely believed to play a causative role in the aging process, follow-up experiments could provide the long-awaited smoking gun connecting AGEs to fundamental mechanisms of aging — and breathe new life into the longstanding search for a clinical use for AGE-breaking compounds like Synvista‘s alagebrium.

(Hat tip to Longevity Meme.)